Search Result

Results for "

S phase arrest

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Aldehyde Dehydrogenase (ALDH) (2) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (5) Apoptosis (76) Aryl Hydrocarbon Receptor (1) Aurora Kinase (1) Autophagy (6) Bcl-2 Family (2) Bcr-Abl (1) c-Kit (1) c-Met/HGFR (2) c-Myc (1) Carbonic Anhydrase (1) Casein Kinase (1) Caspase (1) CDK (12) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (1) COX (1) Deubiquitinase (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (5) Drug Metabolite (1) EGFR (16) Endogenous Metabolite (9) Ferroptosis (1) FLT3 (3) GLUT (2) HDAC (9) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (1) Histone Methyltransferase (3) HPV (1) HSP (2) HSV (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (5) JAK (1) JNK (1) MAPKAPK2 (MK2) (1) MDM-2/p53 (3) Microtubule/Tubulin (2) MMP (2) mTOR (3) Necroptosis (1) NF-κB (1) Nucleoside Antimetabolite/Analog (4) Orthopoxvirus (1) PARP (4) PDGFR (1) PI3K (5) Pim (1) Polo-like Kinase (PLK) (1) PROTACs (1) Raf (4) Ras (1) Reactive Oxygen Species (4) ROS Kinase (1) Sirtuin (1) STAT (1) Stearoyl-CoA Desaturase (SCD) (1) Thymidylate Synthase (2) Topoisomerase (6) Trk Receptor (3) Tyrosinase (2) VEGFR (8)
By Research Areas:	Cancer (108) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (3) Metabolic Disease (2)

By Targets:

Akt (3)

Aldehyde Dehydrogenase (ALDH) (2)

Anaplastic lymphoma kinase (ALK) (1)

Antibiotic (5)

Apoptosis (76)

Aryl Hydrocarbon Receptor (1)

Aurora Kinase (1)

Autophagy (6)

Bcl-2 Family (2)

Bcr-Abl (1)

c-Kit (1)

c-Met/HGFR (2)

c-Myc (1)

Carbonic Anhydrase (1)

Casein Kinase (1)

Caspase (1)

CDK (12)

Checkpoint Kinase (Chk) (2)

Cholinesterase (ChE) (1)

COX (1)

Deubiquitinase (1)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (5)

Drug Metabolite (1)

EGFR (16)

Endogenous Metabolite (9)

Ferroptosis (1)

FLT3 (3)

GLUT (2)

HDAC (9)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Demethylase (1)

Histone Methyltransferase (3)

HPV (1)

HSP (2)

HSV (3)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Isotope-Labeled Compounds (5)

JAK (1)

JNK (1)

MAPKAPK2 (MK2) (1)

MDM-2/p53 (3)

Microtubule/Tubulin (2)

MMP (2)

mTOR (3)

Necroptosis (1)

NF-κB (1)

Nucleoside Antimetabolite/Analog (4)

Orthopoxvirus (1)

PARP (4)

PDGFR (1)

PI3K (5)

Pim (1)

Polo-like Kinase (PLK) (1)

PROTACs (1)

Raf (4)

Ras (1)

Reactive Oxygen Species (4)

ROS Kinase (1)

Sirtuin (1)

STAT (1)

Stearoyl-CoA Desaturase (SCD) (1)

Thymidylate Synthase (2)

Topoisomerase (6)

Trk Receptor (3)

Tyrosinase (2)

VEGFR (8)

By Research Areas:

Cancer (108)

Cardiovascular Disease (2)

Infection (5)

Inflammation/Immunology (3)

Metabolic Disease (2)

117

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N10268

3-Hydroxyterphenyllin NSC 299113	Apoptosis	Cancer
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

HY-147913

PI3K/Akt/mTOR-IN-3	PI3K Akt mTOR Apoptosis	Cancer
PI3K/Akt/mTOR-IN-3 (compound 3d) is a potent PI3K/AKT/mTOR inhibitor. PI3K/Akt/mTOR-IN-3 displays the inhibitory activity in MCF-7, HeLa and HepG2 cells, with IC₅₀ values of 0.77, 1.23, and 4.57μM, respectively. PI3K/Akt/mTOR-IN-3 inhibits the migration of MCF-7 and HeLa cells at the concentration of 4 μM. PI3K/Akt/mTOR-IN-3 induces cell apoptosis and S phase arrest .

HY-156958

S-72	Microtubule/Tubulin STAT Apoptosis	Inflammation/Immunology
S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling .

HY-N10394

Metachromins X

Others Cancer

Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

Metachromins X	Others	Cancer
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-152135

TJ08	Apoptosis	Cancer
TJ08, a 1,2,5-trisubstituted benzimidazole derivative, efficiently induces G1/S phase arrest and promotes apoptosis in various cancer cells. TJ08 is an anticancer agent .

HY-155055

Antiproliferative agent-26	Others	Cancer
Antiproliferative agent-26 (compound 4g) is an antiproliferative agent with much broad range of activity targeting Leukemia, CNS, Melanoma, Renal and Breast (at the concentration of 10 μM). Antiproliferative agent-26 inhibits colony forming and arrests cell cycle at G1 phase/S phase at 5 μM and 25 μM, respectively .

HY-113638

CVT-11127 GS-456332	Stearoyl-CoA Desaturase (SCD) Apoptosis	Cancer
CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer .

HY-13605A

Cytarabine hydrochloride 35+ Cited Publications Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy	Infection Cancer
Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.

HY-111617

BTR-1

Apoptosis Cancer

BTR-1 is an active anti-cancer agent, causes S phase arrest, and affects DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death .

BTR-1	Apoptosis	Cancer
BTR-1 is an active anti-cancer agent, causes S phase arrest, and affects DNA replication in leukemic cells. BTR-1 activates apoptosis and induces cell death .

HY-143302

Anticancer agent 31	Others	Cancer
Anticancer agent 31 is a 1,3-diphenylurea quinoxaline derivative, and a anticancer agent. Anticancer agent 31 exhibits antitumor acitvity by arresting cell cycle at S phase and inducing apoptosis .

HY-N1428A

Citric acid monohydrate 2 Publications Verification
Citric acid monohydrate is a natural preservative and food tartness enhancer. Citric acid monohydrate induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid monohydrate cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid monohydrate causes renal toxicity in mice .

HY-162108

Antitumor agent-128	Apoptosis	Cancer
Antitumor agent-128 (compound 1a) is an antitumor agent that elicits cell cycle arrest in both the G2/M and S phases, triggering apoptosis in A549 cells .

HY-126423

Isorhamnetin 3-glucuronide Isorhamnetin 3-O-glucuronide	Others	Cancer
Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase .

HY-N1428

Citric acid 3 Publications Verification	Apoptosis Endogenous Metabolite Antibiotic	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-155552

GSPT1 degrader-1	Apoptosis	Cancer
GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis .

HY-151978

ZC0109	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Cancer
ZC0109 is a dual inhibitor of IDO1 and thioredoxin reductase 1 (TrxR1) with *IC₅₀s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest* at G1/S phase, thus leads to cancer cells apoptosis .

HY-W016099

3-Methyl-2-quinoxalinecarboxylic acid MQCA	Drug Metabolite	Cancer
3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle .

HY-13768C

Topotecan hydrochloride hydrate SKF 104864A hydrochloride hydrate; NSC 609669 hydrochloride hydrate	Topoisomerase Apoptosis Autophagy	Cancer
Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity .

HY-B2201

Citric acid trisodium 3 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Apoptosis Endogenous Metabolite	Metabolic Disease
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-13605

Cytarabine 35+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus	Infection Cancer
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

HY-118672

HNHA	HDAC MMP HIF/HIF Prolyl-Hydroxylase	Cancer
HNHA is a potent histone deacetylase (HDAC) inhibitor. HNHA arrests the cell cycle at the G1/S phase via p21 induction. HNHA inhibits tumor growth and tumor neovascularization. HNHA may be a potent anti-cancer agent against breast cancer .

HY-150655

Hsp90-IN-15	HSP	Cancer
Hsp90-IN-15 is an Hsp90 inhibitor with anticancer activity. Hsp90-IN-15 induces cell apoptosis, arrests the cell cycle at S phase and decreases the expression level of Hsp90 in Hela cell .

HY-125612

Artonin E 5'-Hydroxymorusin	Apoptosis	Cancer
Artonin E (5'-Hydroxymorusin) is a known prenylated flavonoid that induces apoptosis and arrests the cell cycle in S phase. Artonin E can induce anti-proliferative effects through mitochondrial pathway dysregulation and can be used in cancer research .

HY-161067

EGFR-IN-96	EGFR Apoptosis	Cancer
EGFR-IN-96 (compound 7a) is a thieno[2,3-d]pyrimidine EGFR inhibitor that can induce apoptosis. EGFR-IN-96 arrests the growth of HepG2 cells in the S phase and G2/M phase, and inhibits the growth of cancer cells bearing EGFR wild-type and EGFR ^T790M .

HY-13768

Topotecan SKF 104864A; NSC 609669	Topoisomerase Autophagy Apoptosis	Cancer
Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity .

HY-156298

PARP1-IN-16	PARP Apoptosis	Cancer
PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor, with an IC₅₀ of 1.89 nM. PARP1-IN-16 can arrest the cell cycle in S phase and induce apoptosis in HCT-116 cells .

HY-N1428S4

Citric acid-18O	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Antibiotic	Cancer
Citric acid- ¹⁸O is ¹⁸O-labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-149849

TS-IN-2	Thymidylate Synthase	Cancer
TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor with an IC₅₀ of 0.81 μM. TS-IN-2 induces cancer cell apoptosis and cell cycle arrest in S phase, and also inhibit DNA synthesis, resulting in DNA damage .

HY-155339

Anticancer agent 168	Others	Cancer
Anticancer agent 168 (compound d16) is a inhibitor of DNA2. Anticancer agent 168 induces apoptosis and cell-cycle arrest mainly at S-phase, and exhibits anticancer activities and overcomes chemotherapy resistance in mutp53-bearing cancers .

HY-13605S

Cytarabine-d2	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite	Infection Cancer
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

HY-155609

VEGFR-2-IN-31	VEGFR	Cancer
VEGFR-2-IN-31 (compound 3i) is a potent VEGFR-2 inhibitor (IC₅₀=8.93 nM), and an anti-prostate cancer agent. VEGFR-2-IN-31 arrests cell cycle at the S-phase and induces apoptosis.

HY-N1428S6

Citric acid-d4-1	Isotope-Labeled Compounds Endogenous Metabolite Apoptosis Antibiotic	Cancer
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-108474

Nolatrexed dihydrochloride 1 Publications Verification AG 337; Thymitaq	Thymidylate Synthase	Cancer
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a K_i of 11 nM for human thymidylate synthase . Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity .

HY-N1196

Suberosin
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB .

HY-N1428S3

Citric acid-13C3	Apoptosis Endogenous Metabolite Antibiotic
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-B1508

Vitamin K4 Acetomenaphthone	Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-146407

Anticancer agent 53	Apoptosis	Cancer
Anticancer agent 53 is a potent anticancer agent. Anticancer agent 53 shows in vitro cytotoxicity. Anticancer agent 53 induces apoptosis and cell cycle arrest in S/G2/M phases. Anticancer agent 53 shows antitumor activity with no apparent toxicity .

HY-W278582

Topoisomerase II inhibitor 14	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO .

HY-161146

EGFR-IN-100	EGFR Apoptosis	Cancer
EGFR-IN-100 (compound 3f) is a EGFR inhibitor with IC₅₀ range of 0.137-0.507 μM. EGFR-IN-100 has antiproliferative activity and induces the apoptosis pathway. EGFR-IN-100 arrests the MCF-7 cell cycle at the S phase .

HY-151969

VEGFR-2-IN-30	VEGFR	Cancer
VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC₅₀: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with *IC₅₀s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests* cancer cell at S-phase and induces early and late apoptosis .

HY-145670

cis,trans-Germacrone	Akt MDM-2/p53	Cancer
cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase .

HY-146980

GLUT4-IN-2	Apoptosis GLUT	Cancer
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with *IC₅₀s of 11.4 µM and 6.8 µM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis* and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity .

HY-145963

DRB18	GLUT	Cancer
DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity .

HY-N0273S

Brassinolide-d5 Brassin lactone-d₅	Isotope-Labeled Compounds Apoptosis	Cancer
Brassinolide-d₅ (Brassin lactone-d₅) is the deuterated labeled Brassinolide (HY-N0273). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-N0636

Eriocitrin 1 Publications Verification	Apoptosis	Cancer
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

HY-143246

EGFR kinase inhibitor 1	EGFR Apoptosis	Cancer
EGFR kinase inhibitor 1 is a potent EGFR inhibitor with *IC₅₀s of 37, 1.7, >300 nM for WT, l885R/T790M, L858R/T790M/C797S, respectively. EGFR kinase inhibitor 1 induces apoptosis* and cell cycle arrest at G0/G1-phase. EGFR kinase inhibitor 1 inhibits the cell motility. EGFR kinase inhibitor 1 shows antiproliferative and anti-tumor activity .

HY-15228

RX-3117 1 Publications Verification TV-1360; Fluorocyclopentenylcytosine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis .

HY-145438

Antitumor agent-38	Others	Cancer
Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

HY-146038

Antitumor agent-55	Apoptosis ROS Kinase MDM-2/p53 Bcl-2 Family	Cancer
Antitumor agent-55 (compound 5q) is a potent antitumor agent. Antitumor agent-55 effectively inhibits PC3, with an IC₅₀ of 0.91 μM. Antitumor agent-55 effectively inhibits the colony formation, suppresses the cell migration in PC3. Antitumor agent-55 induces G1/S phase arrest and apoptosis in PC3 .

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)	Isotope-Labeled Compounds Endogenous Metabolite	Others
Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1428

Citric acid 3 Publications Verification	Cardiovascular Disease Structural Classification Preservatives Classification of Application Fields Anti-aging Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Inflammation/Immunology Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Antibiotic
Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-B2201

Citric acid trisodium 3 Publications Verification Sodium citrate; Trisodium citrate anhydrous	Structural Classification Preservatives Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Food Research	Apoptosis Endogenous Metabolite
Citric acid trisodium is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium causes renal toxicity in mice .

HY-N10268

3-Hydroxyterphenyllin NSC 299113	Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields Cancer	Apoptosis
3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .

HY-N10394

Metachromins X	Quinones Structural Classification Classification of Application Fields Animals Terpenoids Sesquiterpenes Marine natural products Benzene Quinones Sponge Disease Research Fields Cancer	Others
Metachromins X is a sesquiterpene quinone that arrests the cell cycle progression of HeLa/Fucci2 cells at S/G2/M phase .

HY-126423

Isorhamnetin 3-glucuronide Isorhamnetin 3-O-glucuronide	Structural Classification Flavonoids Flavones Source classification Endogenous metabolite	Others
Isorhamnetin 3-glucuronide is a potent anticancer agent. Isorhamnetin 3-glucuronide shows anti-proliferative activity. Isorhamnetin 3-glucuronide induces Apoptosis and cell cycle arrest at S-phase .

HY-13605

Cytarabine Maximum Cited Publications 39 Publications Verification Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Sponge Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

HY-B1508

Vitamin K4 Acetomenaphthone	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Vitamin K4 is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system. Vitamin K4 arrests the cells in S phase and induces apoptosis. Vitamin K4 can be used for the research of cancer, such as prostate cancer and osteosarcoma .

HY-N0636

Eriocitrin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Flavonones Source classification Rutaceae Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

HY-128912

Arborinine	Structural Classification Alkaloids Animals Source classification	Histone Demethylase
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity .

HY-N2983

Cajanin	Flavonoids Classification of Application Fields Leguminosae red seaweeds Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Isoflavones	Tyrosinase
Cajanin is a potent and orally active anti-melanogenic agent. Cajanin shows antiproliferative activity in MNT1 Cells. Cajanin efficiently decreases the melanin content. Cajanin down-regulates the mRNA and protein expression levels of MITF, tyrosinase, TRP-1 and Dct (TRP-2). Cajanin induces cell cycle arrest at G2/M and S phase. Cajanin stimulates osteoblast proliferation. Cajanin has the potential for the research of human hyperpigmented disorders and menopausal osteoporosis .

HY-N10503

Norartocarpetin	Structural Classification Flavonoids Flavones Plants Moraceae	Tyrosinase Ras Raf MAPKAPK2 (MK2) Apoptosis
Norartocarpetin is a tyrosinase inhibitor. Norartocarpetin has strong tyrosinase inhibitory activity with an IC₅₀ value of 0.47 μM. Norartocarpetin as an antibrowning agent can be used for the research of food systems. Norartocarpetin also has a significant anticancer activity in lung carcinoma cells (NCI-H460) with an IC₅₀ value of 22 μM. Norartocarpetin has antiproliferative effects are mediated via targeting Ras/Raf/MAPK signalling pathway, mitochondrial mediated apoptosis, S-phase cell cycle arrest and suppression of cell migration and invasion in human lung carcinoma cells .

HY-100513A

Dehydroaltenusin	Structural Classification Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Apoptosis DNA/RNA Synthesis Antibiotic
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC₅₀ value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (K_i=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (K_i=0.18 µM) . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo .

HY-N0316

Mollugin 1 Publications Verification	Monophenols Classification of Application Fields Terpenoids Sesquiterpenes Source classification Rubiaceae Phenols Plants Disease Research Fields Cancer Rubia cordifolia L.	NF-κB Reactive Oxygen Species Apoptosis VEGFR c-Myc
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .

Cat. No.	Product Name	Chemical Structure

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

HY-N1428S4

Citric acid-18O
Citric acid- ¹⁸O is ¹⁸O-labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S6

Citric acid-d4-1
Citric acid-d₄-1 is deuterated labeled Citric acid (HY-N1428) Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.

HY-N1428S3

Citric acid-13C3
Citric acid- ¹³C₃ is the ¹³C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

HY-N0273S

Brassinolide-d5

Brassinolide-d₅ (Brassin lactone-d₅) is the deuterated labeled Brassinolide (HY-N0273). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-P1032S1

Angiotensin I-13C5,15N (human, mouse, rat)

Angiotensin I- ¹³C₅, ¹⁵N (human, mouse, rat) is the ¹³C and ¹⁵N labeled Angiotensin I (human, mouse, rat) (HY-P1032). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice .

HY-W016099S

3-Methyl-2-quinoxalinecarboxylic acid-d4
3-Methyl-2-quinoxalinecarboxylic acid-d₄ is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle[1].

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